Proceedings of the International scientific and practical conference ―Science at the Frontier of Civilizations‖ (March 16-18, 2026) / Publisher website: www.naukainfo.com. – Helsinki, Finland, 2026. - 145 p.

10 EZH2 Epigenetic regulation 1%-2% 1%-2% 7%-10% 7%-13% Associated with aggre- ssive course and reduced overall sur- vival NRAS ERK/MAPK signaling <2% <2% 2%-4% 11% Negative prognostic impact in all subtypes of MPN KRAS ERK/MAPK signaling <2% <2% 2% 4%-7% Negative prognostic impact in all subtypes of MPN SH2B3 JAK signaling regulation 2%-9% 1%-3% 2%-4% 6%-11% Rare muta- tions in JAK2- negative MPN CBL JAK signaling regulation <2% <2% 4% 4% Negative prognostic impact in all subtypes of MPN SRSF2 mRNA splicing <2% <2% 6%-14% 7%-22% Mutations in splicing fac- tor. Common in myelofib- rosis, associ- ated with poor prognosis SF3B1 mRNA splicing 2%-3% 2%-5% 5%-7% 7%-11% Negative prognostic impact in ET U2AF1 mRNA splicing <2% <2% 7%-10% 5%-12% Negative prognostic impact in all subtypes of MPN NFE2 Transcription factor 3%,6% 1%-7% 3%-5% ? Increased risk of leuke-mic transfor-mation