Proceedings of the International scientific and practical conference ―Science at the Frontier of Civilizations‖ (March 16-18, 2026) / Publisher website: www.naukainfo.com. – Helsinki, Finland, 2026. - 145 p.

5 BIOLOGY AND BIOTECHNOLOGY UDC 577 213/.216: 577.213/.215 Voroniak Myroslav candidate of biological sciences, senior scientist Shurko Nataliya candidate of biological sciences, senior scientist Khudzii Sofiia scientist Kokoruz Maryana scientist Laboratory of Molecular Genetics, State Institution ―Institute of Blood Pathology and Transfusion Medicine of the National Academy of Medical Sciences of Ukraine‖, Lviv NON-DRIVER MUTATIONS IN CHRONIC MYELOPROLIFERATIVE NEOPLASIAS Abstract: Chronic myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematological cancers with varying rates of progression. Genomic characterization of patients with such disorders opens up the potential for personalized diagnosis, risk stratification, and treatment. It is known that the leading role in this is played by the so-called driver mutations JAK2, CALR, MPL. In recent years, other, non-driver mutations have been discovered, which are also important in the diagnosis, prognosis, and therapy of these diseases. The paper reviews the role of such mutations in myeloproliferative diseases.