Proceedings of the International scientific and practical conference ―Science, technology and art in global context‖ (October 14-16, 2025) / Publisher website: www.naukainfo.com. – Warsaw, Poland, 2025. - 72 p.

47 the course will help optimize patient treatment, as some scientific studies indicate that antiviral therapy may be useless in uncomplicated cases of IM [4]. The goal is to predict the unfavorable course of IM in children based on the results of clinical and laboratory research. 110 children aged from 3 to 13 years with angina-glandular form of IM were under observation, of which 64 (58.18%) had an uncomplicated favorable course, 46 (41.82%) had a prolonged course. The children were comparable in terms of disease severity, age, and gender. IM was most frequently registered among children aged six to ten years (41.82%), least often among children aged three to five years (23.63%). In our cohort of observations, girls were slightly more likely to be ill (55.46%). The diagnosis of MI was verified based on clinical and epidemiological data, and on the basis of relevant markers using ELISA and PCR methods. Treatment of all patients was carried out in accordance with diagnostic and treatment standards. Manifestations such as fever, signs of tonsillitis (lacunar form predominated), enlarged lymph nodes, pale skin, hepatomegaly were recorded in all children at the onset of IM (100%). The obtained data coincide with the generally known clinical signs of IM [1,5]. It was found that in patients with IM with an unfavorable course at the onset, pain syndrome in the oropharynx was weakly expressed (p<0.05), while abdominal pain (p<0.05) and lymphoproliferative syndrome were significantly more pronounced – a significant difference was found between the observation groups in the size of the cervical and submandibular lymph nodes, which were larger in patients with an unfavorable course of IM (р<0,05). In these same patients, enlarged mesenteric lymph nodes were also significantly more frequently recorded. (р<0,05). Significant differences between patients of observation groups were established regarding the size of the liver and spleen. In patients with an unfavorable course of IM at the onset, the size of the parenchymal organs was significantly larger (p<0.05). An increase in the size of the spleen over 1.1 cm was 2 times more often determined in the unfavorable course of IM (р<0,05). Patients with an unfavorable course of IM at the onset of the disease have significantly higher C-reactive protein (CRP), ESR, and segmented neutrophil