Proceedings of the International scientific and practical conference ―Science, technology and culture: integration and prospects‖ (November 3-5, 2025) / Publisher website: www.naukainfo.com. – Kharkiv, Ukraine, 2025. - 254 p.

83 MEDICAL SCIENCES AND PUBLIC HEALTH UDC 616.12-092.9:547.486 Shevchenko Inna Volodymyrivna candidate of medical sciences, associate professor Dnipro State Medical University, Dnipro https://orcid.org/0000-0001-7928-9094 Kushnarova Kateryna Anatolyivna candidate of medical sciences, associate professor Dnipro State Medical University, Dnipro https://orcid.org/0000-0002-6827-5313 CARDIOTOXIC EFFECT OF LEAD ACETATE Introduction. Acute intoxication with lead acetate negatively affects cardiogenesis and functional parameters of the heart. Lead acetate causes hemorrhages, necrotic changes in the myocardium, inflammatory and cicatricial changes, but the ultrastructural basis of the cardiotoxic effect is not sufficiently studied. The aim of the work is to investigate the structural basis of the cardiotoxic effect of lead acetate. Object and research methods. Pregnant female Wistar rats (average weight 200-220 g) received 2.5% aqueous solution of lead acetate (50 mg/kg, 1 time/day, 2 weeks) before the onset of pregnancy and throughout the entire period of the experiment. The control group consisted of intact animals. On the 1st and 7th day of postnatal development, material (the apex of the left ventricle of the heart) was collected for electron microscopic examination. The samples were fixed in a 2.5%