Proceedings of the International scientific and practical conference ―Modern Science: Challenges and Perspectives‖ (February 9-11, 2026) / Publisher website: www.naukainfo.com. - London, United Kingdom, 2026. - 121 p.

100 MEDICAL SCIENCES AND PUBLIC HEALTH UDC 616.523+616.428-006+616-053.2 Mateiko Halyna Bohdanivna Doctor of Medical Sciences, Professor Horbal Nataliia Bohdanivna Senior lecturer Ivano-Frankivsk National Medical University Ivano-Frankivsk, Ukraine Nesterova Tetiana Volodymyrivna Pediatrician, children infectious diseases specialist Bukovel Medical Center, Polianytsia, Ivano-Frankivsk Oblast, Ukraine EBV-ASSOCIATED GENERALIZED LYMPHADENOPATHY Abstract . Lymphadenopathy, most commonly of bacterial or viral etiology, occurs in 55% of children under the age of 10. It may be a manifestation of lymphoproliferative disorders, including lymphomas. Lymphoproliferative diseases are characterized by uncontrolled lymphocyte proliferation, monoclonal lymphocytosis, lymphadenopathy, and bone marrow infiltration. Because of the oncogenic potential of Epstein–Barr virus (EBV), persistent lymphadenopathy in patients with ongoing EBV infection requires increased clinical vigilance. Aim: To increase physicians’ awareness of the risk of developing EBV-associated lymphoproliferative disorders in children with generalized persistent lymphadenopathy. A clinical case of a 14-year-old female patient with chronic EBV infection and persistent lymphadenopathy is presented. Immunohistochemical