Proceedings of the International scientific and practical conference ―Modern Science: Challenges and Perspectives‖ (February 9-11, 2026) / Publisher website: www.naukainfo.com. - London, United Kingdom, 2026. - 121 p.

106 shape. Mitotic activity of the follicular center cells was expressed (B-cell–dependent zone). The paracortical zone and the interfollicular space (T-cell–dependent zone) were more markedly expanded. No reliable morphological signs of tumor growth were identified in the material. Conclusion: lymph node hyperplasia with predominance of T-cell–dependent zone hyperplasia. Because of the differences between diagnoses (Hodgkin lymphoma diagnosed at the Department of Oncohematology and Intensive Chemotherapy of the Municipal Nonprofit Enterprise ―Ivano-Frankivsk Regional Children’s Clinical Hospital of the Ivano-Frankivsk Regional Council‖ and the diagnosis of Lviv National Medical University, which refuted it), the histological specimens were sent to the Pathology Department of the Kyiv City Oncology Hospital for an independent expert evaluation. Microscopic description of the cervical lymph node : The architecture is disrupted due to a large number of hypertrophied lymphoid follicles with active germinal centers. The mantle zone surrounding the follicles is thinned. The interfollicular space contains a large number of macrophages, histiocytes, activated B lymphocytes, as well as numerous vessels with edematous endothelium. In one of the sections, partial effacement of the tissue architecture is observed, with indistinct contours of the lymphoid follicles. This area was selected for immunohistochemical examination. Immunohistochemical findings: CD45 (PD7/26): positive membranous staining in the majority of cells of the lymph node parenchyma. CD30 (Bcr-H2): positive membranous staining in occasional large cells showing Golgi apparatus staining, making them highly similar to Hodgkin cells; however, such cells are few in number. CD15 (BY87): negative. Conclusion: The morphological features of the examined lymph node are consistent with reactive hyperplasia, with signs of expressed immune blast transformation within the lymphoid follicles and the presence of occasional CD30-positive cells, possibly activated B lymphocytes. Given the presence of large CD30-positive cells in one area of the lymph node, strict clinical follow-up is needed, and in the absence of positive dynamics, a repeat biopsy is recommended.