Proceedings of the International scientific and practical conference ―Science at the Frontier of Civilizations‖ (March 16-18, 2026) / Publisher website: www.naukainfo.com. – Helsinki, Finland, 2026. - 145 p.

55 Arthrospira platensis exhibit pronounced antimicrobial activity against pathogens of bacterial and fungal diseases of bees [7, с. 6312–6314]. Some scientific works demonstrate the interaction of beekeeping products and probiotic cultures, which can influence the formation of the microbiological environment in the body of insects [8, с. 420–421]. Analysis of experimental materials showed that the use of the probiotic "Apinormin" helps increase the viability of bees and reduce their natural mortality rate [3, с. 44–45]. The combined use of the probiotic "Apinormin" and the product "Anolite" demonstrated a positive effect in laboratory conditions. It was established that such a feeding scheme does not have a toxic effect and contributes to a decrease in the dynamics of natural mortality of worker bees by 3.7–19.5% compared to the control group [5 с. 72–78]. Maintaining the optimal composition of the intestinal microflora, in particular bacteria of the genus Lactobacillus , plays an important role in forming the body's resistance to pathogenic microorganisms [6, с. 5–6]. In addition, the results of other scientific works confirm that biologically active metabolites of natural origin are capable of inhibiting the development of pathogens of infectious diseases of bees, which emphasizes the prospects for the use of biological agents in the system of prevention of honey bee pathologies [7, с. 6315– 6317]. REFERENCES: 1. Melnyk V. V., Shevchenko O. V. Veterynarno-sanitarni zakhody profilaktyky khvorob bdzhil v Ukraini // Ahrarna nauka ta praktyka. 2024. No. 1. S. 73–80. 2. Rudenko Ye. V., Maslii I. H., Kamyshan N. V. Indykatsiia zbudnykiv infektsiinykh khvorob bdzhil u produktakh bdzhilnytstva // Bdzhilnytstvo Ukrainy. 2023. No. 1. P. 11–18. https://doi.org/10.46913/beekeepingjournal.2023.11.12