Proceedings of the International scientific and practical conference ― Education and Scientific Progress‖ (February 13-15, 2026) / Publisher website: www.naukainfo.com. - Manchester, United Kingdom, 2026. - 206 p.

82 stimulators of the expression of various regenerative genes in the gastrointestinal tract, in particular in hypergastrinemia, which occurs precisely after water immersion stress and in patients infected with Helicobacter pylori [1, 3, 7]. The approach of Gast expression level to physiological values 24 hours after the stressor is eliminated, and the decrease in catalase activity may be involved in the activation of healing processes by modeling the immune response and reducing inflammation, which gradually leads to the restoration of Gast gene expression pattern. Thus, we have shown that under conditions of stress-induced lesions of the gastrointestinal tract cells of rats, against the background of changes in catalase activity, the expression of the Gast gene increased, while after the cessation of the stressor, its decrease was observed. The data obtained suggest that gastrin may be involved in accelerating wound healing. REFERENCES: 1. Zhou Z., Huang P., Song G., Zhang Z., An K., Lu H.-W., Ju X.-L., Ding W. Comparative proteomic analysis of rats subjected to water immersion and restraint stress as an insight into gastric ulcers. Molecular Medicine Reports, 2017. Vol. 16. P. 5425–5433. 2. Zhao D.-Q., Xue H., Sun H.-J. Nervous mechanisms of restraint water- immersion stress-induced gastric mucosal lesion. World J Gastroenterol, 2020. Vol. 26, no. 20. P. 2533–2549. 3. Kazumori H., Ishihara S., Hoshino E., Kawashima K., Nobuyuki M., Suetsugu H., Sato H., Adachi K., Fukuda R., Watanabe M., Takasawa S., Okamoto H., Fukui H., Chiba T., Kinoshita Y. Neutrophil chemoattractant 2b regulates expression of the Reg gene in injured gastric mucosa in rats. Gastroenterology, 2000. Vol. 119. P. 1610–1622. 4. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction. Anal Biochem, 1987. Vol. 162, no 1. P. 156–159.