Proceedings of the International scientific and practical conference ―Science, technology and cultural innovations‖ (October 7-9, 2025) / Publisher website: www.naukainfo.com. – Vienna, Austria, 2025. - 138 p.

79 and hirsutism) and reproductive disorders in women (ovulation disorders, infertility, and miscarriage) [1]. In addition, secondary hypoestrogenia can be a trigger of atherogenic vasculopathy and, as a result, it leads to cardiovascular and metabolic risks. This is also facilitated by oxidative stress, carbohydrate metabolism disorders, and chronic inflammation [2]. Clinical guidelines recommend identifying adolescent girls with PCOS. However, adolescents who have signs of PCOS but do not meet the diagnostic criteria are recommended to be classified as ―at increased risk‖ and referred for re- examination at the time of full reproductive maturity or 8 years after menarche [3, p. 51]. In our opinion, if from the moment of establishing the risk of PCOS to the period of full reproductive maturity, there is not to react for the pathological changes occurring in the body of an adolescent girl, then this time will be sufficient for the formation of manifest PCOS with all its endocrine and metabolic disorders. It is during this period that minimal medication can prevent significant hormonal and immunological pathogenetic changes in the body caused by PCOS. For adolescent girls with a risk of developing PCOS, there are no established methods for preventing the progression of negative pathogenetic changes in the ovaries, and there are no protocols for correcting metabolic syndrome and insulin resistance. It is precisely in such patients that there is a risk of cognitive and behavioral disorders and stigmatization due to excess weight. These symptoms should be given special attention, as their increase can lead to anxiety and depression, close to suicidal behavior [4]. In order to prevent the development of negative pathogenetic changes in the ovaries, we have developed a method of preventive treatment for adolescent girls with an increased risk of polycystic ovary syndrome. This treatment helps prevent menstrual cycle disorders and weight gain, predict insulin resistance, reduce hirsutism, and improve overall self-esteem in adolescent girls at risk for PCOS.