Proceedings of the International scientific and practical conference “Multidisciplinary approaches in science, technology and culture” (October 21-23, 2025) / Publisher website: www.naukainfo.com. – Berlin, Germany, 2025. - 121 p.

78 UDC 591.3:612.392:546.815 Shevchenko Inna Volodymyrivna candidate of medical sciences, associate professor Dnipro State Medical University, Dnipro https://orcid.org/0000-0001-7928-9094 Kushnarova Kateryna Anatolyivna candidate of medical sciences, associate professor Dnipro State Medical University, Dnipro https://orcid.org/0000-0002-6827-5313 Gruzd Vladyslava Volodymyrivna PhD Dnipro State Medical University, Dnipro, https://orcid.org/0000-0002-3630-6031 WEIGHT CHANGES IN RATS AND OFFSPRING UNDER LEAD ACETATE INTOXICATION Introduction. Establishing the features of the morphogenesis of organs of different systems in a comparative embryological aspect in the norm, as well as changes in their structural and functional organization due to the negative impact of the environment is a priority task of modern morphology. In the development of general issues of biology and medicine, a significant place should be occupied by research on the patterns of development of tissues, organs and systems of the human and animal body at different stages of onto- and phylogenesis, respectively. cientific interest in the specifics of the impact of anthropogenic factors on the body is caused by significant environmental pollution with heavy metals, with lead and its compounds being the priority toxicant. Under the influence of lead acetate concentrations, the heart mass of rat embryos decreases, and certain changes occur in its structure: the thickness of the ventricular wall and the interventricular septum