Proceedings of the International scientific and practical conference “Multidisciplinary approaches in science, technology and culture” (October 21-23, 2025) / Publisher website: www.naukainfo.com. – Berlin, Germany, 2025. - 121 p.

79 decreases due to thinning of the compact myocardium, myocardial trabeculae become refined, do not form bridges and do not contain vessels. Research objective . To investigate changes in the weight of rats and offspring during the prenatal stage of development under conditions of lead acetate exposure and exposure to lycopene and inulin. Object and methods of research. The studies were conducted on female Wistar rats. The animals were kept under standard vivarium conditions. The experimental model was reproduced by administering a 2.5% solution of lead acetate at a rate of 50 mg/kg of rat body weight per day. The solution was administered intragastrically via a gavage once a day daily throughout the entire pregnancy. Aqueous solutions of lycopene and inulin were administered in a similar manner at a rate of 500 mg/kg of rat body weight per day. Females in the control group received distilled water. The study material was the hearts of embryos on days 14, 16 and 18 of gestation. The animals were divided into four groups:група 1 – control group – intact animals; group 2 – experimental group – animals that were chronically exposed to lead acetate; group 3 – experimental group of animals that were administered lycopene against the background of chronic use of lead acetate; group 4 – experimental group of animals that were administered inulin against the background of chronic use of lead acetate. The study material was the hearts of rat embryos on days 14, 16, and 18 of prenatal development. Research results and their discussion. The weight of the experimental rats (according to the weight monitoring diary) at the end of the observation period changed, namely did not reach the values of the control group of rats. A statistically significant decrease in the weight of the experimental group of rats with lead acetate - animals from which embryos were received at stages 14, 16 and 18 of prenatal development was detected almost throughout the entire observation period. Analysis of changes in the weight of the experimental groups of rats that received lead acetate and the studied agents - inulin and lycopene - did not show a statistically significant