Proceedings of the International scientific and practical conference ―Synergy of Modern Science and Education‖ (February 2-4, 2026) / Publisher website: www.naukainfo.com. – New York, USA, 2026. - 324 p.

116 deficiency: hypothalamic amenorrhea (the body saves energy), which further leads to the disappearance of ovulation and an irregular cycle [4]. Follicle-stimulating hormone and the effect of minerals on its functioning. Zinc - a regulator at the hypothalamus level. Zn deficiency disrupts the synthesis of GnRH, which leads to insufficient stimulation of FSH synthesis, impaired follicle growth and estradiol synthesis. Selenium - as a component of glutathione peroxidase, provides antioxidant protection of pituitary and ovarian cells. Se deficiency leads to oxidative stress, which disrupts the ability of FSH to adequately stimulate folliculogenesis and ovulation [5]. Iron, its deficiency (iron deficiency anemia) leads to tissue hypoxia, impaired general metabolism and hormone synthesis, which contributes to anovulation and reduced fertility. Magnesium affects the level of FSH through two mechanisms: anti-stress: reduces the level of cortisol, which suppresses the production of GnRH and metabolic: improves insulin sensitivity, the violation of which (insulin resistance) is a pathogenetic link in PCOS and the cause of FSH imbalance. Luteinizing hormone, the effect of minerals. Zinc, necessary for the synthesis of the protein part of LH in the pituitary gland. Improves the sensitivity of ovarian receptors to LH, which is critical for the ovulatory peak and the function of the corpus luteum. Magnesium stabilizes the hypothalamus and reduces stress (cortisol- mediated) inhibition of LH release. Selenium, protects oocytes and ovarian cells from oxidative stress, supporting their ability to respond adequately to the LH signal [6]. Estrogen. Magnesium, modulates the estrogen/progesterone balance by supporting liver function, where estrogen inactivation occurs. Demonstrates the ability to reduce estrogen levels in the blood, especially in postmenopause [7]. Calcium, correlates with a decrease in estrogen levels in the blood. Interacts with estrogen in the maintenance of bone tissue through the regulation of osteoclasts/osteoblasts. Copper, demonstrates a dual effect: necessary for enzymes, but an excess increases oxidative stress. Copper levels correlate with estrogen levels. Progesterone. Zinc is critical for the synthesis of LH, which stimulates the production of progesterone by the corpus luteum. Ensures normal function of the